Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production.
-
WbpW and PslB are redundant PMI/GMPs for A-band LPS.
"indicating that A-band LPS synthesis requires the redundant PMI/GMP activity of either PslB or WbpW to generate product."
-
WbpW supplies GDP-D-mannose for Psl when PslB is absent.
"Together, the attachment, immunoblot, and ELISA data confirm that, in a pslB mutant, WbpW is the PMI/GMP responsible for generating the GDP-d-Man essential in the production of Psl."
Synthesis of the A-band polysaccharide sugar D-rhamnose requires Rmd and WbpW: identification of multiple AlgA homologues, WbpW and ORF488, in Pseudomonas aeruginosa.
-
wbpW complements E. coli PMI and GMP mutants, indicating bifunctional PMI/GMP activity.
"To confirm the enzymatic activity of WbpW, Escherichia coli PMI and GMP mutants deficient in the K30 capsule were complemented with wbpW, and restoration of K30 capsule production was observed."
-
wbpW mutants make very little A-band LPS.
"The Rmd mutants do not produce A-band LPS, while the WbpW mutants synthesize very low amounts of A band after 18 h of growth."
UniProt entry Q9HTB7 (wbpW)