Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
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ATG7 forms a homodimer
"Cross-linking experiments and glycerol-gradient centrifugation analysis showed that the mammalian Apg7p homolog forms a homodimer as in yeast Apg7p"
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Cys572 is the active site cysteine essential for thioester intermediate formation
"Cys(572) of hApg7p is an authentic active site cysteine residue essential for the formation of the hApg7p.hApg12p intermediate"
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ATG7 is an E1-like enzyme for ATG12 and ATG8 family proteins
"hApg7p is an authentic protein-activating enzyme for hApg12p and the three Apg8p homologs"
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification.
Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
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Acetylated FOXO1 binds ATG7 to induce autophagy
"the acetylated FoxO1 bound to Atg7, an E1-like protein, to influence the autophagic process"
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ATG7 required for autophagy under starvation and oxidative stress
"Endogenous FoxO1 was required for autophagy in human cancer cell lines in response to oxidative stress or serum starvation"
Network organization of the human autophagy system.
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation.
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FAP motif (F15-A16-P17) essential for ATG7-ATG3 interaction
"the FAP motif of ATG7 is essential for the interaction of ATG7 with ATG3"
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FAP motif required for LC3 lipidation
"ATG7 is an autophagy-related E1-like enzyme that is essential for two ubiquitination-like reactions, ATG12-conjugation and LC3-lipidation"
Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes.
Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.
Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes.
Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Global Proximity Interactome of the Human Macroautophagy Pathway.
Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3.
ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.
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K63-linked ubiquitination of ATG7 at K45 by TRIM32
"We show that CHK2 binds and phosphorylates TRIM32 at the S55 site, which then mediates K63-linked ubiquitination of ATG7 at the K45 site to initiate autophagy."
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ATG7 ubiquitination promotes ATG8/ATG12 activating enzyme activity
"Oxidative stress-induced autophagy helps to prevent cellular damage and to maintain homeostasis"
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ATG7 localization at phagophore assembly site
"We propose a molecular mechanism for autophagy initiation by ROS via the ATM-CHK2-TRIM32-ATG7 axis to maintain intracellular homeostasis and to protect cells exposed to pathological conditions from stress-induced tissue damage."
ATG3 transfers LC3 from ATG7 to ATG3
LC3:ATG7 dimer binds ATG3
ATG7:ATG3:LC3 dissociates
Exocytosis of secretory granule lumen proteins
Exocytosis of ficolin-rich granule lumen proteins
ATG12 forms a thioester bond with ATG7 dimer