TCTN1 notes

Deep research: skipped because the providers are unavailable here. The review is based on UniProt Q2MV58 and on PMID:21725307 and PMID:16357211, which were fetched in full text.

Key findings

• Tctn1 forms a complex with MKS/JBTS proteins PMID:21725307.
• It localizes to the transition zone PMID:21725307.
• It is required for a subset of interactors to reach the transition zone PMID:21725307. NPHP1 and NPHP4 localize independently of it.
• Its requirement for ciliogenesis is tissue-specific PMID:21725307.
• It regulates Hedgehog signaling downstream of Smo and Rab23 PMID:16357211. No NEW Hedgehog term was added, because the effect is most likely a consequence of the ciliary gate function. This is raised as a suggested question.
• TCTN1 has a signal peptide. The extracellular region and Reactome cytosol rows were marked over-annotated.