Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled.

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch.

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction.

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF.

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis.

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections.

Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling.

Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha.

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.

Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding.

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression.

JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.

Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2

Phosphorylated SHC1 recruits GRB2:GAB2

Phosphorylated SHC recruits GRB2:SOS1

Gab2 binds the p85 subunit of Class 1A PI3 kinases

RAS GEFs promote RAS nucleotide exchange

CSF2RA:CSF2RB binds SFTPs

SFTPs translocate from extracellular region to clathrin-coated vesicle

Defective CSF2RB does not bind SFTPs

Defective CSF2RA does not bind SFTPs

Tyrosine kinases phosphorylate the receptor

Activation of STAT5a/b by JAK2

JAK2 is phosphorylated, activated

SHC1 bound to the common beta chain becomes tyrosine phosphorylated

STAT5 is recruited by JAK2

Recruitment of SHC1 is mediated by Y593 of the common beta chain

The receptor is activated

SHP1 and SHP2 bind the common beta chain

SHC1 mediates cytokine-induced phosphorylation of GAB2

p-S585-IL3RB binds 14-3-3 proteins

Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

GM-CSF receptor alpha:GM-CSF binds Bc

Phosphorylated SHC1 recruits SHIP

The SHC1:SHIP1 complex is stabilized by GRB2

IL3RB is phosphorylated on Ser-585

SHP1 and SHP2 dephosphorylate Y628 of IL3RB

14-3-3 zeta binding allows recruitment of PI3K

p-STAT5 dissociates from the receptor complex

Mouse JAK2 binds human common beta chain

IL-9 receptor signaling in memory B cells regulates humoral recall responses.

Cloning of rat interleukin-3 receptor beta-subunit from cultured microglia and its mRNA expression in vivo.

Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.

CSF2RB source evidence and original-access locators