Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Novel salivary antihemostatic activities of long-form D7 proteins from the malaria vector Anopheles gambiae facilitate hematophagy
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D7L1 (AngaD7L1) binds leukotriene C4 and thromboxane A2 analog U-46619
"We found that AngaD7L1 binds leukotriene C4 and thromboxane A2 analog U-46619"
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D7L1 inhibits U-46619-induced platelet aggregation and vasoconstriction
"functional assays confirmed AngaD7L1 inhibits U-46619-induced platelet aggregation and vasoconstriction"
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D7L1 is a vasodilator that inhibits vasoconstriction to U-46619
"A. gambiae salivary D7L1 and D7L3 proteins are vasodilators"
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D7L1 had dose-dependent inhibitory effect on platelet aggregation
"When platelet aggregation was initiated with U-46619, AngaD7L1 had a dose-dependent inhibitory effect on platelet aggregation"
UniProt entry for D7L1_ANOGA (Long form salivary protein D7L1)
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D7L1 modulates blood feeding by binding host mediators
"Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response"
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D7L1 binds leukotriene C4 and thromboxane A2 analog
"Binds leukotriene C4 and U-46619, a stable analog of thromboxane A2 (PubMed:35460690)"
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D7L1 inhibits platelet aggregation
"Inhibits agonist- induced platelet aggregation (PubMed:35460690)"
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D7L1 exhibits vasodilating activity
"Exhibits vasodilating activity (PubMed:35460690)."
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D7L1 is secreted
"SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18153}."