Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:11502704

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins.

Pulmonary-artery smooth-muscle isolates from patients have altered growth responses to BMP/TGF-beta ligands; only a subset carried detected BMPR2 variants.

PMID:12045205

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension.

BMPR2 mutations produce distinct trafficking and BMP/SMAD-signaling defects; mutant, but not wild-type, constructs activate p38 in the reported NMuMG assay.

PMID:12819188

The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells.

BMP2 promotes lung-cancer-cell growth and migration in the abstract; the receptor-specific experimental conditions underlying the BMPR2 source annotations remain unresolved.

PMID:15188402

Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.

BMPR-II cytoplasmic constructs capture signaling-associated proteins from C2C12 extracts; PKC beta and CtBP associations were independently confirmed.

PMID:15657086

Dynamics and interaction of caveolin-1 isoforms with BMP-receptors.

Caveolin-1 isoforms associate with BMP receptors and affect their membrane organization.

PMID:17992660

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.

Human pulmonary endothelial BMPRII perturbation alters BMP-dependent signaling and cellular responses in a vascular-development context.

PMID:18326817

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.

Hemojuvelin-dependent hepcidin signaling uses a selective BMP receptor system that includes BMPRII and ActRIIA.

PMID:18364108

A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension.

BMPR2 Glu386Val segregates with familial pulmonary arterial hypertension in the reported pedigree.

PMID:18382765

An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.

BMP2/BMPRII-dependent PPARgamma/apoE signaling restrains PASMC proliferation; the described PPARgamma response is independent of SMAD1/5/8 phosphorylation.

PMID:18436533

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.

Primary human mesenchymal-cell BMP signaling depends on BMPR2 and ACVR2A to differing extents for BMP2/4 versus BMP6/7.

PMID:19229295

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.

GDF5/type-I receptor recognition is structurally characterized; GDF5 binding to BMPRII is independently corroborated by PMID21976273.

PMID:19366699

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells.

BMPRII and ActRII have overlapping and distinct roles in BMP9/ALK1 signaling in human pulmonary arterial endothelial cells.

PMID:19424179

Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity.

cGKI associates with and phosphorylates BMPRII, then participates in downstream nuclear SMAD-dependent transcriptional regulation.

PMID:21791611

TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

TSC-22 associates with BMPRII in the reported co-immunoprecipitation experiment.

PMID:21976273

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.

GDF5-S94N has impaired BMPRII binding and altered noggin sensitivity, separating receptor recognition from antagonist resistance.

PMID:22664934

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.

The study profiles tear-fluid proteins in breast-cancer and control samples.

PMID:22684006

MicroRNA-100 regulates osteogenic differentiation of human adipose-derived mesenchymal stem cells by targeting BMPR2.

miR-100 targets BMPR2 RNA, and BMPR2 RNAi inhibits osteogenic differentiation of human adipose-derived mesenchymal cells.

PMID:24407287

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.

An ASC interaction screen supplies the provenance for the BMPR2 co-complex assertion.

PMID:25187962

Functional changes in pulmonary arterial endothelial cells associated with BMPR2 mutations.

BMPR2 variants differ in intracellular localization and effects on pulmonary endothelial proliferation, apoptosis and vasoactive mediators.

PMID:25468996

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

E-cadherin-associated proximity/proteomic experiments provide the source context for an adherens-junction annotation.

PMID:26598555

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling.

Endothelial BMPRII associates with VE-cadherin and SRC in receptor-associated signaling complexes.

PMID:33308444

SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.

SCUBE3 associates with BMPRII independently of added BMP ligand in the reported co-IP, whereas its type-I receptor association is ligand-dependent.

PMID:36931259

A central chaperone-like role for 14-3-3 proteins in human cells.

A 14-3-3 interaction screen is the source of the BMPR2-YWHAE assertion.

PMID:9442116

Bone morphogenetic protein signaling is required for maintenance of differentiated phenotype, control of proliferation, and hypertrophy in chondrocytes.

Dominant-negative human BMPR2 disrupts differentiated and hypertrophic phenotypes, reduces matrix-associated readouts and increases proliferation in chick chondrocytes.

Reactome:R-HSA-201443

Type II receptor phosphorylates type I receptor

The constitutively active type-II receptor phosphorylates the type-I receptor GS region; the model does not establish an exact ATP stoichiometry.

Reactome:R-HSA-201451

Signaling by BMP

Reactome:R-HSA-201453

Phospho-R-Smad1/5/8 dissociates from the receptor complex

Reactome:R-HSA-201457

BMP2 binds to the receptor complex

Reactome:R-HSA-201475

I-Smad competes with R-Smad1/5/8 for type I receptor

Reactome:R-HSA-201476

Activated type I receptor phosphorylates R-Smad1/5/8 directly

Activated type-I receptor phosphorylates R-SMAD1/5/8 downstream of BMPR2; BMPR2 is not thereby assigned direct SMAD kinase activity.

Reactome:R-HSA-201648

An anchoring protein, Endofin, recruits R-Smad1/5/8

Reactome:R-HSA-201821

I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated

Reactome:R-HSA-202604

Formation of a heteromeric BMP receptor complex

PMID:35504921

Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.

Human BMPRII extracellular-domain structures establish direct BMP10 knuckle-epitope recognition in binary and ternary receptor assemblies.

PMID:19903896

ALK1 signaling regulates early postnatal lymphatic vessel development.

ALK1-pathway perturbation affects blood and lymphatic vascular development.

PMID:17114649

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

Mouse synaptosomal phosphoproteomics provides the donor-study context for the postsynaptic localization transfer.

file:human/BMPR2/BMPR2-uniprot.txt

UniProtKB Q13873 (BMPR2_HUMAN), bone morphogenetic protein receptor type-2

Human BMPR2 is a single-pass receptor kinase with two named products; the canonical long cytoplasmic tail provides regulatory interaction sites.