GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:11991638

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

CWC27 is present in native affinity-purified spliceosomes consisting largely of C complex, the basis for its catalytic step 2 spliceosome annotation.

PMID:20676357

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

The tested human CWC27 domain lacks detectable tetrapeptide isomerase activity and CsA binding, while peptide binding is observed.

PMID:29360106

Structure of the human activated spliceosome in three conformational states.

CWC27 is strong in early human Bact, weaker in the mature class and absent in late Bact.

PMID:33509932

Structure of the activated human minor spliceosome.

CWC27 is a component of the activated human minor spliceosome that splices U12-type introns.

PMID:39068178

Molecular basis for the activation of human spliceosome.

CWC27 is present in Bact-I and dissociates during transition to Bact-II in the six-state activation series.

PMID:28285769

Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies.

Biallelic loss-of-function variants in CWC27 cause autosomal-recessive retinitis pigmentosa with or without skeletal/developmental anomalies (RPSKA).

Reactome:R-HSA-9770131

Formation of the Spliceosomal B* complex

Reactome:R-HSA-9770145

Formation of the Spliceosomal Bact complex

Reactome:R-HSA-9921507

NS5 interacts with Spliceosome

file:human/CWC27/CWC27-deep-research-falcon.md

Falcon deep research report for CWC27

Secondary synthesis proposes a noncatalytic spliceosomal and CWC22-associated role; primary studies refine its catalytic, state and EJC-mechanism claims.

PMID:32329775

Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes.

PMID:42635127

Assembly of exon junction complexes on spliceosomes begins before spliceosome activation.

file:human/CWC27/CWC27-uniprot.txt

Official UniProt CWC27 record and alternative products

file:human/CWC27/CWC27-source-evidence.json

CWC27 source evidence and stage/product assessment

file:human/CWC27/CWC27-primary-source-notes.md

CWC27 primary experimental evidence: public locators and interpretation