Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
Suppressor mutations identify amino acids in PAA-1/PR65 that facilitate regulatory RSA-1/B″ subunit targeting of PP2A to centrosomes in C. elegans.
Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans.
-
MEG-1 and MEG-3 are substrates of MBK-2 and PP2A(PPTR-1/2); dephosphorylation promotes P granule assembly.
"Phosphorylation of the MEGs promotes granule disassembly and dephosphorylation promotes granule assembly."
Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans.
-
pptr-1 mutant P granules are unstable during mitosis and partition symmetrically.
"We have identified a mutant (pptr-1) in which P granules become unstable during mitosis and P granule proteins and RNAs are distributed equally to somatic and germline blastomeres."
The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans.
-
let-92, paa-1 and pptr-1 are each needed for UV resistance of older adults.
"we found that three genes encoding the subunits to constitute a complete PP2A complex consisting of the catalytic subunit LET-92 along with the regulatory subunit PPTR-1 and the scaffold PAA-1 were required for Day 6 adults to resist ultraviolet irradiation"