Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.

NEK7 is a centrosomal kinase critical for microtubule nucleation.

Mitotic regulation by NIMA-related kinases.

An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

High-throughput RNAi screening reveals novel regulators of telomerase.

Anks3 alters the sub-cellular localization of the Nek7 kinase.

Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression.

A reference map of the human binary protein interactome.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Cryo-EM structures of the active NLRP3 inflammasome disc.

Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation.

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation.

Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.

The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.

Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.

IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.

Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3.

Human cytomegalovirus protein US18 promotes NLRP3 inflammasome activation.