Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
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MIB E3 ligases mediate K63 ubiquitination of TBK1.
"Detailed mechanistic analysis defined a role for mind bomb (MIB) E3 ligases in K63-linked ubiquitination of TBK1, a kinase that phosphorylates IRF transcription factors controlling interferon production."
The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein.
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy.
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis.
A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants
Falcon deep research report on human MIB1
UniProtKB entry Q86YT6 (MIB1_HUMAN)
A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.
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MIB1 MZM and REP domains bind two distinct JAG1 tail epitopes; both needed for efficient ubiquitination and signaling.
"Mib1 contains two independent substrate recognition domains that engage two distinct epitopes from the cytoplasmic tail of the ligand Jagged1, one in the intracellular membrane proximal region and the other near the C terminus."