ERG26 (YGL001C) notes

UniProt P53199; sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating), EC 1.1.1.170; 3beta-HSD family; peripheral ER membrane [UniProt:P53199].

Evidence journal

• erg26 accumulates carboxysterols; disruption lethal in heme-competent cells PMID:9811880.
• erg26-1 microsomes lack activity; GFP-Erg26 ER PMID:11279045.
• Cofactor: full text of PMID:9811880 does not assay NAD+ vs NADP+; only cites NAD-depleted microsome work in other systems.

Decisions

• GO:0000252 core (cofactor-neutral); GO:0102175 (NAD+-specific, IMP) KEEP_AS_NON_CORE; generic CH-OH oxidoreductase IEA -> MODIFY GO:0000252; protein binding REMOVE (incl. MCM7 AP-MS hits); RCA cytosol -> ER membrane.