"transfection and expression of the FzE3 cDNA in esophageal carcinoma cells stimulates complex formation between adenomatous polyposis coli (APC) and beta-catenin followed by nuclear translocation of beta-catenin"

"coexpression of FzE3 with Lef-1 transcription factor enhanced beta-catenin translocation to the nucleus"

"cotransfection of a mutant construct encoding a FzE3 protein with a C-terminal truncation completely inhibited the interaction of APC with beta-catenin in cells"

"Daple preferentially binds the cytoplasmic tail of the FZD7R"

"Daple competes with Dvl for binding to FZDRs and antagonizes Wnt signaling via the β-catenin/TCF/LEF pathway"

"This triggers non-canonical Wnt responses, that is, suppresses the β-catenin/TCF/LEF pathway and tumorigenesis, but enhances PI3K-Akt and Rac1 signals"

"TcdB binds to the conserved Wnt-binding site known as the cysteine-rich domain (CRD), with the highest affinity towards FZD1, 2 and 7"

"These findings establish FZDs as physiologically relevant receptors for TcdB in the colonic epithelium"

"The PDZ domains of syntenin also interact for example with certain Frizzled receptors (for example, Frizzled 3, -7 and -8)"

"The presence of 0.5 mM IP3 increases the apparent affinity of syntenin PDZ2 for Frizzled 7"

"We determine that asparagine 215, and lysines 214 and 250 in the PDZ2 domain, and lysine 569 in Frizzled 7 (further referred to as lysine-5 in the carboxy-terminal fragment) are essential for membrane PIP2-specific recognition"

"When co-expressed, Frizzled 7 and eYFP-PDZ1-PDZ2 strongly localize to the plasma membrane"

"the band intensities of c-Jun, p-JNK and p-c-Jun were decreased by FZD7_siRNA"

"FZD7 may be involved in enhancement of survival, invasion and metastatic capabilities of colon cancer cells through non-canonical Wnt signalling pathways as well as the canonical pathway"

"overall survival was shorter in those patients with higher FZD7 expression (P<0.001)"

"Fzd4 interacts preferentially with PDZ2"

"Fzds 2, 4 and 7 showed impaired Wnt-induced β-catenin activation in the presence of NHERF1 (76%, 86% and 74% decrease, respectively)"

"the binding of NHERF1 to Fzd should reduce Fzd-Dvl pre-coupling and result in impaired Wnt-induced Fzd internalization"

"FZD7 mRNA levels in human ES cells are up to 200-fold higher compared to differentiated cell types"

"ShRNA-mediated knockdown of FZD7 in human ES cells induced dramatic changes in the morphology of ES cell colonies, perturbation of expression levels of germ layer-specific marker genes, and a rapid loss of expression of the ES cell-specific transcription factor OCT4"

"These findings identify the WNT receptor FZD7 as a novel ES cell-specific surface antigen with a likely important role in the maintenance of ES cell self-renewal capacity"

"we generated cell lines with multiplex mutant alleles of FZD1, FZD2, and FZD7 and demonstrate that these cells are unresponsive to canonical Wnt ligands"

"we performed genetic rescue experiments with combinations of FZDs and canonical Wnts to create a functional ligand-receptor interaction map"

"Interaction of myocilin with sFRP1, sFRP3, and several Frizzled receptors was confirmed by immunoprecipitation experiments"

"Treatment of NIH 3T3 cells with myocilin and its fragments induced intracellular redistribution of beta-catenin"

"syntenin also interacts with the C-terminal PDZ binding motif of several Frizzled Wnt receptors"

"Syntenin stimulates c-jun phosphorylation and modulates Frizzled 7 signaling, in particular the PKCalpha/CDC42 noncanonical Wnt signaling cascade"

"syntenin-Frizzled 7 binding mode indicates syntenin can accommodate Frizzled 7-syndecan complexes"

"a specific Wnt3-FZD7 interaction was observed by co-immunoprecipitation experiments, which suggest that the action of Wnt3 was mediated via FZD7"

"Activation of the Wnt/beta-catenin pathway in FOCUS-Wnt3 cells was demonstrated by beta-catenin accumulation, enhanced TCF transcriptional activity and proliferation rate"

"The activation of Wnt/beta-catenin signaling in FOCUS-Wnt3 was abolished by a knockdown of FZD7 expression by siRNA"

"The Dvl PDZ domain is known to interact directly with a peptide derived from the KTXXXW motif of Fz7, which is conserved in all known Fz subtypes"

"we transiently expressed Fzd 2 and Fzd7, two receptors shown to mediate Wnt3a signaling in 293 cells"

"FZD7 and FRS2 were confirmed as miR-1 targets using luciferase reporter assay and western blot"

"Wnt signaling regulates multiple cellular functions and cell systems, including the development and maintenance of midbrain dopaminergic (mDA) neurons"

"FZD7 is necessary for MET of the monolayer cells as loss of FZD7 results in the persistence of a mesenchymal state"

"sFRP-1 can interact with Wnt receptors Frizzled 4 and 7 on endothelial cells to transduce downstream to cellular machineries requiring Rac-1 activity"

"Here, we apply state-of-the-art cryo-EM to elucidate the apo structure of FZD7 with an overall resolution of 1.9 Å (FSC 0.143)."

"we identified a conserved cholesterol-binding site, which displays a key role in FZD7 association with a transducer protein, Disheveled (DVL), and initiation of downstream signaling and signalosome formation."

"The double mutants completely abrogated FZD7-DEP recruitment, suggesting that cholesterol plays a key role in constitutive DVL recruitment by FZDs"

"the molecular switch R6.32-W7.55 acts as a hinge limiter (Fig. 3c, d) permitting only a restricted TM6 opening (11°, 5.5 Å). Hence, the open conformation of FZDs remains suboptimal for G protein coupling providing a rational explanation for the limited capacity of FZDs to couple to heterotrimeric G proteins and their propensity to display selectivity towards DVL over heterotrimeric G proteins"

"FZDs prefer coupling to DVL rather than heterotrimeric G proteins and that distinct active state micro-switches in the receptor are essential for pathway selection arguing for conformational changes in the receptor protein defining transducer selectivity."

"We find that RNF43 preferentially down-regulates FZD1/FZD5/FZD7, whereas ZNRF3 displays a preference towards FZD6."