Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
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atf-6 acts synergistically with pek-1 to complement the developmental requirement for ire-1 and xbp-1
"in C. elegans, atf-6 acts synergistically with pek-1 to complement the developmental requirement for ire-1 and xbp-1"
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deletion of either ire-1 or xbp-1 is synthetically lethal with deletion of either atf-6 or pek-1
"deletion of either ire-1 or xbp-1 is synthetically lethal with deletion of either atf-6 or pek-1, both producing a developmental arrest at larval stage 2"
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atf-6 regulates few i-UPR genes following ER stress, but is required for the expression of many c-UPR genes
"C. elegans atf-6 regulates few i-UPR genes following ER stress, but is required for the expression of many c-UPR genes, indicating its importance during development and homeostasis"
APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses.
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ER stress induced transcription of apy-1 requires both ire-1 and atf-6
"This increase was not observed in C. elegans mutants defective in ire-1 or atf-6, demonstrating the requirement of both ER stress sensors for up-regulation of apy-1"
Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.
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pharmacological induction of misfolded proteins requires the UPR pathway proteins IRE-1, XBP-1, and ATF-6
"pharmacological induction of misfolded proteins is itself sufficient to stimulate a delayed protective response to hypoxic injury that requires the UPR pathway proteins IRE-1, XBP-1, and ATF-6"
A novel interaction between aging and ER overload in a protein conformational dementia.
Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.
Developmental defects in a Caenorhabditis elegans model for type III galactosemia.
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interactions between gale-1 and the unfolded protein response
"Interestingly, we found interactions between gale-1 and the unfolded protein response"
Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.
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atf-6 loss of function enhances tau toxicity
"atf-6 loss of function in Tau (low) animals enhances mild behavioral defects observed in a liquid environment"
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atf-6 loss abolishes XBP-1s-mediated tauopathy suppression
"atf-6 loss of function abolishes the ability of neuronal overexpression of xbp-1s in Tau (high) animals to suppress severe behavioral defects"
Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis.
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atf-6 deletion extends lifespan by 43-57%
"we found that the atf-6 deletion mutant was significantly long-lived (57% increase in median, p < 0.0001; Figure 1B)"
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atf-6 regulates calreticulin/crt-1 expression
"crt-1(bz29) mutants are long-lived to a similar extent as atf-6(ok551) (38%, p < 0.001 versus wild-type; Figure 2E)"
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atf-6 influences ER-mitochondrial calcium signaling
"loss of the mitochondrial calcium importer, mcu-1, reduces atf-6-mediated lifespan extension by 67% (p < 0.0001 compared to atf-6(ok551); Figure 4G)"
Deep research on C. elegans atf-6 gene function
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ATF-6 functions as one of three UPR branches
"The UPRER has three branches: IRE-1/xbp-1, PERK/pek-1, and ATF-6/atf-6"
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atf-6 deletion extends lifespan
"atf-6(ok551) deletion increases median lifespan by 57% (p < 0.0001), and an independent CRISPR null increases lifespan by 43% (p < 0.0001)"