Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.

Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis.

The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein.

Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.

p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner.

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.

Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes.

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.

Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.

Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.

Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes.

Regulation of p73 by Hck through kinase-dependent and independent mechanisms.

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis.

Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils.

Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X.

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix).

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma.

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.

Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS.

Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).

A proteome-scale map of the human interactome network.

Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK.

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.

Membrane Anchoring of Hck Kinase via the Intrinsically Disordered SH4-U and Length Scale Associated with Subcellular Localization.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Nucleotide binding domain and leucine-rich repeat pyrin domain-containing protein 12: characterization of its binding to hematopoietic cell kinase.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae.

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

Nef Binds and activates the Src-family tyrosine kinase Hck

Sequestering and phosphorylation Fc gamma receptors in the lipid rafts

Fcgamma receptor (FCGR) dependent phagocytosis

Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers

FCGR3A-mediated IL10 synthesis

FCGR3A-mediated phagocytosis

p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7

CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane

UniProtKB record for human HCK