Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.
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STA-2 is a STAT-like transcription factor that interacts with the SLC6 transporter SNF-12
"the STAT transcription factor-like protein STA-2 as a direct physical interactor of SNF-12"
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STA-2 and SNF-12 function together to regulate antimicrobial peptide expression in epidermis
"the two proteins function together to regulate AMP gene expression in the epidermis"
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Both proteins act cell autonomously in the epidermis
"Both SNF-12 and STA-2 act cell autonomously and specifically in the epidermis to govern the transcriptional response to fungal infection"
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Activation mechanism is distinct from classical JAK-STAT signaling
"These findings reveal an unorthodox mode of regulation for a STAT factor"
The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.
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STA-2 acts downstream of PKC/TPA-1 and the p38 MAPK pathway
"This cascade acts upstream of the STAT-like transcription factor STA-2"
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STA-2 is required for nlp-29 induction after infection
"This cascade acts upstream of the STAT-like transcription factor STA-2"
Structural damage in the C. elegans epidermis causes release of STA-2 and induction of an innate immune response.
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STA-2 is associated with hemidesmosomes in the epidermis
"hemidesmosomes associated with a STAT-like protein"
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Structural damage to hemidesmosomes triggers STA-2 release
"whose disruption led to detachment of STA-2 molecules from hemidesmosomes"
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Released STA-2 translocates to nucleus and activates AMP transcription
"detachment of STA-2 molecules from hemidesmosomes and transcription of AMPs"
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Only apical hemidesmosome disturbance triggers immune response
"only disturbance of the apical hemidesmosomes triggered an immune response"
An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development.
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STA-2 works with ELT-3 to activate V-ATPase expression at molts
"mediated by the GATA transcription factor ELT-3 and the STAT family protein STA-2"
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ECM-epidermis attachment disturbance triggers lysosomal activation via STA-2
"mediated by the GATA transcription factor ELT-3 and the STAT family protein STA-2"
Mechanisms of innate immunity in C. elegans epidermis.
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STA-2 and ELT-3 are both required for epidermal nlp AMP gene transcription.
"Both the STAT family protein STA-2 and the GATA transcription factor ELT-3 are required for the transcription of nlps"
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SNF-12 binds STA-2 and the two co-localise in endocytic vesicles.
"SNF-12 physically interacts with the transcription factor STA-2 and they have been found to colocalise in dyn-1-dependent-endocytic vesicles"
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STA-2 is nuclear and hemidesmosome-associated, and binds the apical hemidesmosome component MUP-4.
"STA-2 was found in the nucleus but also associated with hemidesmosomes (CeHDs)"
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How STA-2 is activated downstream of p38 MAPK is unresolved.
"It is still not clear how p38 MAPK-dependent STA-2 activation and trafficking are regulated in C. elegans epidermis."
Comparative evolutionary genomics of the STAT family of transcription factors.
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STA-2 (F58E6.1) is a highly divergent, nematode-specific STAT-like paralog of STA-1.
"Therefore, F58E6.1 probably shared a common ancestor with STA-1, arose through a gene duplication event specific to the nematode lineage, and survived through rapid sequence diversification and neofunctionalization, although its current function remains to be determined."
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In unpublished EMSA, F58E6.1 did not bind a STAT consensus motif.
"co-expression of F58E6.1 with a tyrosine kinase in mammalian tissue culture system failed to show any DNA binding activities using a STAT consensus DNA sequence motif in electrophoretic mobility shift assay"
Deep research report on sta-2
OpenScientist focused report on whether STA-2 retains a functional STAT DNA-binding domain
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STA-2 keeps the STAT DNA-binding-domain fold but fails the Pfam STAT DNA-binding-domain profile that STA-1 passes and conserves none of the three base-contacting residues of DNA-bound STAT1.
"STA-2 (Q20977) does NOT match PF02864"
UniProt entry for C. elegans sta-1 (Q9NAD6)
UniProt entry for C. elegans sta-2 (Q20977)