GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:PSEPK/PP_4332/PP_4332-uniprot.txt

UniProtKB/TrEMBL entry Q88EX0 (PP_4332)

Unreviewed entry with a single CheW-like domain (PROSITE PS50851) and CheW-subfamily classification (InterPro IPR039315, PANTHER PTHR22617:SF23); no curated free-text annotation.

PMID:11923283

CheW binding interactions with CheA and Tar. Importance for chemotaxis signaling in Escherichia coli.

CheW binding to both receptor and CheA is required for ternary complex activity and chemotaxis.

"mutations which eliminate CheW binding to Tar (V36M) or to CheA (G57D) result in a complete inability to form active ternary complexes in vitro and render the CheW protein incapable of mediating chemotaxis in vivo"

PMID:1992467

Signal transduction in bacteria: CheW forms a reversible complex with the protein kinase CheA.

PMID:21606342

Core unit of chemotaxis signaling complexes.

file:projects/P_PUTIDA/deep-research/PSEPK__bacterial_chemotaxis_signal_transduction__ppu02030-deep-research-openscientist.md

OpenScientist PSEPK bacterial chemotaxis signal transduction (ppu02030) synthesis

The roles of the two adjacent CheW paralogs are unresolved.

"PP_4332 (CheW) and PP_4333 (CheW domain protein) are adjacent paralogs."