Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo.
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npp-20 (CeSec13R) RNAi gives 100% embryonic lethality, irregular nuclear morphology and blocked cytokinesis (full text, PMC284812; read from PMC web page, not in cache).
TFG-1 function in protein secretion and oncogenesis.
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SEC-13 localizes next to ER exit sites and on germline nuclear envelopes, and forms a SEC-13-SEC-31 heterotetramer.
"Dual immuno-gold labeling with TFG-1 and SEC-13 antibodies indicated that both proteins localize to an identical area next to ER exit sites, although the SEC-13 labeling was more discrete"
Nucleoporins NPP-10, NPP-13 and NPP-20 are required for HCP-4 nuclear import to establish correct centromere assembly.
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NPP-20 is required for prophase nuclear import of HCP-4/CENP-C.
"Following the knockdown of NPP-10, NPP-13 and NPP-20, HCP-4 remains in the cytosol throughout prophase due to stalled import."
Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.
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npp-20 recovered in a C. elegans RNAi screen for NMD factors; human SEC13 required for NMD; worm npp-20 RNAi causes L2-L3 larval arrest.
"Importantly, we show that two human homologs, GNL2 (ngp-1) and SEC13 (npp-20), are also required for NMD in human cells."
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
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Human SEC13 is a GATOR2 subunit that promotes mTORC1 signalling.
"inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, and Sec13) suppresses mTORC1 signaling"
Detecting Gene Ontology misannotations using taxon-specific rate ratio comparisons.
UniProtKB Q9N4A7 record for C. elegans npp-20