cep-1 notes

2026-09-30

• Completed the worm cep-1 review as the final C. elegans CED-pathway comparator
  in the APOPTOSIS slice. CEP-1 was curated as the nuclear p53-family
  sequence-specific transcription activator that induces egl-1 and ced-13
  BH3-only transcription after genotoxic stress, engaging the
  CED-9/CED-4/CED-3 intrinsic apoptosis module. The core DNA-damage branch is
  supported by the original cep-1 germline-apoptosis paper PMID:11696333,
  the HUS-1/egl-1 checkpoint paper PMID:12445383, the ced-13 induction paper
  PMID:15605074, UV-C and genome-wide transcriptional profiling studies
  [PMID:17347667; PMID:18627611], and PRMT-5/CBP-1 modulation of
  CEP-1-dependent egl-1 induction PMID:19521535.
• Tightened generic transcription rows. GO:0003677 DNA binding,
  GO:0003700 DNA-binding transcription factor activity, and broad
  GO:0006355 regulation of DNA-templated transcription rows were moved toward
  GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific or GO:0045944 positive regulation of transcription by RNA polymerase II, using the CEP-1 p53 response-element evidence from the DNA
  binding-domain and fasn-1 target-gene studies [PMID:15242600;
  PMID:16582625].
• Kept the PRMT-5/CBP-1 transcription repressor complex as a real but non-core
  regulatory assembly, kept ER-stress/IRE-1-triggered p53-mediated germline
  apoptosis as a non-DNA-damage branch, and retained hypoxia, starvation,
  lifespan, and meiotic chromosome-segregation rows as non-core stress or
  genome-quality phenotypes rather than direct apoptotic outputs.
• Marked the SMG-1 paraquat row to GO:0006979 response to oxidative stress
  as over-annotated for CEP-1: smg-1 inactivation produces cep-1-dependent
  oxidative-stress resistance, but the experiment is an endpoint epistasis
  assay and does not show that CEP-1 itself directly executes an oxidative
  stress response PMID:18836529.
• Left four rows unresolved pending full-text or structural evidence: the old
  RAD-51 IGI apoptosis row from an abstract-only rad-51 paper
  PMID:12684824, the two zinc-binding rows whose direct seeded paper concerns
  the C-terminal oligomerization/SAM domain PMID:17581633, and the old
  nucleolus localization row from the abstract-only founding CEP-1 paper
  PMID:11557844.