Ing5 (Q9VJY8) review notes
- ING family; subunit of Enok complex. PMID:27198229
- Required for H3K23ac. PMID:27198229
- Decisions: shared Enok complex conventions (see enok-notes.md); H3K4me3 reader IBA accepted (conserved ING PHD); protein-containing complex IEA MODIFY -> MOZ/MORF complex.
Deep research (falcon, added after initial review)
Ing5-deep-research-falcon.md agrees that Ing5 is a non-enzymatic Enok complex subunit that promotes Enok chromatin association and H3K23ac ["Its experimentally demonstrated contribution is to promote Enok association with nuclear chromatin and appropriate histone H3 lysine-23 acetylation"]. It reports a regulated cytosolic pool (Tctp binds the PHD region and retains Ing5) and developmental roles (EGFR, Hippo/Yki) from a 2023 study not in GOA. It cautions that H3K4me3 reading is inferred from the ING family, not measured in fly; the IBA is kept as a phylogenetic inference. No annotation decisions changed.
PR 4481 review fixes
- Core molecular function changed from GO:0140002 H3K4me3 reader (IBA only, no fly measurement) to GO:0010698 acetyltransferase activator activity plus contributes_to GO:0043994; H3K4me3 recognition is now described in prose as a family inference. The IBA row stays ACCEPT as a phylogenetic inference.