Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming.
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ZSWIM8 is the substrate adaptor of a Cullin-RING ubiquitin ligase that mediates TDMD.
"We identified a cullin-RING ubiquitin ligase (CRL), containing the substrate adaptor ZSWIM8, that mediates TDMD."
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.
The ZSWIM8 ubiquitin ligase regulates neurodevelopment by guarding the protein quality of intrinsically disordered Dab1.
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ZSWIM8 participates in protein quality control by regulating DAB1 quality.
"Mechanistic studies reveal that ZSWIM8 controls protein quality of Disabled 1 (Dab1), a key signal molecule for brain development, thus protecting the signaling strength of Dab1."
UniProt text export for ZSWIM8 (A7E2V4)
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UniProt describes ZSWIM8 as a substrate-recognition component of a TDMD-promoting E3 ligase.
"Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation"
Falcon deep research report for ZSWIM8
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Falcon research supports ZSWIM8 as the core substrate-recognition subunit of the TDMD Cullin-RING ligase.
"ZSWIM8 is best-supported as the substrate-recognition subunit of a Cullin-RING ubiquitin ligase (CRL) complex that executes TDMD by targeting Argonaute proteins."