Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta.

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.

Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion.

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.

Structural basis of the Axin-adenomatous polyposis coli interaction.

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

A human protein-protein interaction network: a resource for annotating the proteome.

Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity.

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.

Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation.

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.

Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.

Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.

The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.

Kaiso is a bimodal modulator for Wnt/beta-catenin signaling.

Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.

Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization.

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.

Axin localizes to the centrosome and is involved in microtubule nucleation.

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.

Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.

AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.

Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling.

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin.

Toward an understanding of the protein interaction network of the human liver.

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.

Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

The protein interaction landscape of the human CMGC kinase group.

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response.

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

OpenCell Endogenous tagging for the cartography of human cellular organization.

Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded.

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.

Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis.

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β.

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.

I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling.

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions.

Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.

Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon.

Phosphorylation of APC in the destruction complex

Dissociation of beta-catenin from Axin and association with phospho-APC

GSK3 phosphorylation of beta-catenin at Ser37

GSK3 phosphorylation of beta-catenin at Thr41

GSK3 phosphorylation of beta-catenin at Ser33

Association of beta-catenin with destruction complex

CK1alpha phosphorylation of beta-catenin at Ser45

Beta-catenin association with SCF(beta-TrCP) complex

Degradation of ubiquitinated beta-catenin

Multi-ubiquitination of phospho-beta-catenin

AXIN phosphorylation in destruction complex

Misspliced GSK3beta mutants stabilize beta-catenin

AXIN mutants destabilize destruction complex

AXIN ubiquitination by SMURF2

Ubiquitinated AXIN degradation

RNF146 ubiquitinates ADP-ribosylated AXIN

USP34 deubiquitinates AXIN1/AXIN2

Ub-RibC-AXIN degradation by proteasome

RNF146 binds RibC-AXIN:TNKS complex

Tankyrase ADP-ribosylates AXIN

DVL recruits GSK3beta:AXIN1 to receptor complex

Assembly of the destruction complex

Phosphorylation of LRP5/6 cytoplasmic domain

Beta-catenin release from destruction complex

Tankyrase binds AXIN

SMURF2 binds AXIN

APC truncation mutants have impaired AXIN binding

CTNNB1 S45 mutants not phosphorylated by CK1alpha

CTNNB1 S33 mutants not phosphorylated by GSK3beta

CTNNB1 S37 mutants not phosphorylated by GSK3beta

CTNNB1 T41 mutants not phosphorylated by GSK3beta

Truncated AMER1 mutants destabilize destruction complex

Expression of AXIN1 gene

WNT3A stimulates caveolin-dependent internalization

AXIN1 gene expression regulated by ESR1 and RUNX1

CK1gamma phosphorylates LRP5/6 (frog model)

Deep research report on AXIN1