Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans.
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xbx-1 is required for retrograde IFT and is homologous to the mammalian dynein light intermediate chain D2LIC.
"xbx-1, that is required for retrograde IFT and shares homology with a mammalian dynein light intermediate chain (D2LIC)"
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XBX-1 functions together with the CHE-3 dynein heavy chain in retrograde IFT, downstream of the IFT-A (complex A) proteins.
"the DLIC protein XBX-1 functions together with the CHE-3 dynein in retrograde IFT, downstream of the complex A proteins"
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XBX-1 localizes to the ciliary base and moves bidirectionally (anterograde and retrograde) along the axoneme.
"XBX-1 localizes to the base of the cilia and undergoes anterograde and retrograde movement along the axoneme"
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Loss of xbx-1 produces short cilia with a distal bulb in which IFT proteins accumulate, the hallmark of retrograde IFT failure.
"they are shortened and have a bulb like structure in which IFT proteins accumulate"
Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans.
The BBSome controls IFT assembly and turnaround in cilia.
Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron.
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans.