Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.
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BBS5 identified as a novel BBS gene required for cilia and flagella formation
"this novel protein localizes to basal bodies in mouse and C. elegans, is under the regulatory control of daf-19, and is necessary for the generation of both cilia and flagella"
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BBS-5 localizes to basal bodies in C. elegans
"this novel protein localizes to basal bodies in mouse and C. elegans"
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BBS-5 expression is under regulatory control of daf-19 (RFX transcription factor)
"is under the regulatory control of daf-19"
The BBSome controls IFT assembly and turnaround in cilia.
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BBSome assembles IFT complexes at ciliary base
"the in vivo function for the BBSome is to regulate the assembly of the IFT particles at the ciliary base"
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BBSome regulates IFT turnaround at ciliary tip
"the BBSome may play a similar role in IFT reassembly and turnaround at cilia tip"
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BBS-5 is part of the BBSome complex with BBS-1, -2, -4, -7, -8, -9
"the others (BBS-2, -5, -7, -8, -9) only showed very dim ciliary staining when compared to wild-type animals"
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BBSome binds to anterograde IFT particles and travels to ciliary tip
"After IFT particles are assembled at the ciliary base, the BBSome binds to the IFT particle like a cargo but not a structural component"
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors.
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BBS-5 and BBS-4 are functionally redundant in ciliogenesis
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Double mutants show defective cilia structure and IFT protein localization
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BBS-5 interacts directly with BBS-4 C-terminus
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Required for removal of degraded mechanosensory receptors from cilia
Deep research report on bbs-5