SGD gene description for LAT1 (yeast)
The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension.
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lat1 deletion abolishes CR-induced life span extension; Lat1 overexpression extends life span, largely requiring respiration and not the Sir2 family.
"Deleting the LAT1 gene abolishes life span extension induced by CR."
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
YeastPathways to GO-CAM conversion
Subcellular localization of the yeast proteome.
Global analysis of protein localization in budding yeast.
The proteome of Saccharomyces cerevisiae mitochondria.
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases.
Disruption and mutagenesis of the Saccharomyces cerevisiae PDX1 gene encoding the protein X component of the pyruvate dehydrogenase complex.
Overexpression and mutagenesis of the catalytic domain of dihydrolipoamide acetyltransferase from Saccharomyces cerevisiae.
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
Pyruvate dehydrogenase complex from baker's yeast. 2. Molecular structure, dissociation, and implications for the origin of mitochondria.
Expression, purification, and characterization of the dihydrolipoamide dehydrogenase-binding protein of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae.
On the unique structural organization of the Saccharomyces cerevisiae pyruvate dehydrogenase complex.