LAMP2 notes

Deep research (falcon / perplexity-lite) failed; notes from cached publications and UniProt P13473.

• Type I lysosomal membrane glycoprotein; luminal domain 29-375, TM 376-399, cytoplasmic 400-410 (UniProt).
• Principal location intracellular lysosomes; minor PM fraction in some cells PMID:2912382. Shuttles lysosome/endosome/PM (UniProt, PMID:17897319). Surface after degranulation (Reactome platelet/neutrophil degranulation).
• LAMP-2A = CMA receptor PMID:11082038; multimeric translocation complex PMID:18644871.
• LAMP1/2 inhibit TMEM175 -> lysosomal acidification PMID:37390818.
• Needed for STX17 recruitment and autophagosome-lysosome fusion PMID:27628032.
• Stabilizes TAPL PMID:22641697.

Localization conclusion: lysosomal/late endosomal membrane (type I, luminal domain inside lumen); minor/transient PM pool
with luminal domain exposed extracellularly (CD107b, upregulated on degranulation). Not a constitutive surface protein.