Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis.
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ARL6IP1/ARMER is an ER integral membrane protein with four predicted transmembrane domains
"We demonstrate that ARMER is an endoplasmic reticulum (ER) integral membrane protein with four predicted transmembrane domains and a COOH-terminal KKXX ER retrieval motif"
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Overexpression protects cells from multiple apoptotic stimuli including ER stressors
"Cells in which ARMER was overexpressed exhibited protection from multiple apoptotic inducers including serum starvation, doxorubicin, UV irradiation, tumor necrosis factor alpha, and the ER stressors brefeldin A, tunicamycin, and thapsigargin"
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Inhibits caspase-9 activity but not cytochrome c release or caspase-9 cleavage
"Analysis of the caspase proteolytic cascade reveals that ARMER inhibits proteolysis of the caspase-9-specific fluorogenic substrate LEHD-AFC as well as endogenous substrates downstream of caspase-9; however, it does not inhibit cytochrome c release or cleavage of caspase-9 itself"
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Apoptotic stimuli cause ARMER levels to decrease
"Apoptotic stimuli cause endogenous levels of ARMER protein and RNA to decrease, leading to cell death"
Towards a proteome-scale map of the human protein-protein interaction network.
An empirical framework for binary interactome mapping.
Defining the membrane proteome of NK cells.
Next-generation sequencing to generate interactome datasets.
Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.
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ARL6IP1 contains reticulon-like short hairpin transmembrane domains
"Arl6IP1, which does not share an overall primary sequence homology with reticulons, harbours reticulon-like short hairpin transmembrane domains"
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Binds to atlastin (ATL1), a GTPase mediating tubular ER network formation
"binds to atlastin, a GTPase that mediates the formation of the tubular ER network"
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Overexpression induces extensive ER tubules and excludes luminal proteins
"Overexpression of Arl6IP1 induced extensive tubular structures of the ER and excluded a luminal protein"
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Stabilizes ER tubules even in absence of microtubules
"overexpression of Arl6IP1 stabilized the ER tubules, allowing the cells to maintain the ER tubules even in the absence of microtubules"
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Constricts liposomes into tubules in vitro
"Arl6IP1 constricted liposomes into tubules"
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Hairpin transmembrane domains required for membrane-shaping activity
"The short hairpin structures of the transmembrane domains were required for the membrane-shaping activity of Arl6IP1"
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Preferentially localizes to ER tubules and sheet edges
"Arl6IP1 has the ability to shape high-curvature ER tubules in a reticulon-like fashion"
A proteome-scale map of the human interactome network.
Identification and characterization of TMEM33 as a reticulon-binding protein.
Widespread macromolecular interaction perturbations in human genetic disorders.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
An inter-species protein-protein interaction network across vast evolutionary distance.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia.
A proteome-scale map of the SARS-CoV-2-human contactome.
Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.