Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria.
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Mouse muscle and myocyte experiments connect mitochondrial Sdhaf2 availability to complex-II assembly and activity; they do not isolate the 135-residue alternative product.
"Restoration of Sdhaf2 normalized complex II
activity, lipid oxidation, and insulin action in Drp1-KD myocytes."
Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase kinase 3β-β-catenin-mediated lung cancer metastasis.
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The study reports an EMT-marker phenotype in SDH5 knockout mouse lung epithelium, i.e. a loss-of-function (necessity) phenotype rather than evidence of participation in EMT regulation.
"In SDH5 knock-out mice, lung epithelial cells exhibited elevated mesenchymal markers, which is characteristic of EMT."
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Human lung-cell experiments link SDH5 to GSK3-beta/beta-catenin regulation in a context-dependent mechanism, rather than establishing a universal Wnt effect of all products.
"SDH5 functions as a negative regulator of Wnt-β-catenin signaling."
Exact Sdhaf2 product and mitochondrial-targeting sequence comparison
Frozen exact-input ProtNLM output and UniProt sequence for A0A494B8X4
Sdhaf2 re-review structural-feature mapping of A0A494B8X4
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein.
PAINT IBD/IRD assertions for PANTHER PTHR12469