Gene Ontology annotation through association of InterPro records with GO terms

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:24684232

A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.

Bacterial group II GGGPS enzymes are distinguished from group I HepGP synthases; target-specific experimental detail is in the reviewed record.

"the previously uncharacterized bacterial enzymes from group II have GGGPS activity like the archaeal enzymes and differ from the bacterial group I enzymes that are heptaprenylglyceryl phosphate synthases."

file:FLAJ1/Fjoh_1584/Fjoh_1584-uniprot.txt

Frozen reviewed UniProtKB A5FJK8 record

Record establishes strain, locus, curated mechanistic family and target-specific structural linkage.

file:analysis/module_audits/bacterial_heptaprenylglyceryl_ether_lipid/comparative-members/identity-and-scope.md

Comparative-member structural identity and reaction-scope audit

Official PDBe mappings separate the two bacterial PcrBs, bacterial C20 GGGPS, and archaeal structural comparator.

file:analysis/module_audits/bacterial_heptaprenylglyceryl_ether_lipid/comparative-members/PMID24684232-fulltext-scope.md

Primary full-text assay-host, mutant and structural scope check

Host-dependent donor tests and engineered mutant specificity must not be treated as native pathway completeness or wild-type C35 capability.