FBXL4 supplies substrate recognition in an SCF ubiquitin ligase. The reviewed core links receptor ubiquitination/proteasomal turnover to negative regulation of mitophagy, while retaining distinct source limits for topology, contextual nuclear staining, pathway-model compartments and pairwise interaction screens.
The primary and database guides retain the finite reading scope of each lane. The combined review applies the accepted whole-reference successors and includes the four shared primary scopes exactly once. Inherited quotations remain in their original positions; an older quotation is not silently revised to erase a subsequently identified conflict.
The single core does not imply exclusive mitochondrial localization. The older intermembrane-space experiment remains UNDECIDED, while the ten modeled cytosolic Reactome placements are MARK_AS_OVER_ANNOTATED for overextending generic ligase-set compartment evidence. The target entity itself carries cytosol; an exclusive-compartment claim is not made. HPA nuclear-speck staining remains contextual. The two bounded gaps concern the conflicting topology observations and context-dependent PPTC7 recruitment/mutant/dosage results. No engineered targeting construct is represented as a natural product, and no additional GO annotation or quotation is introduced.
The two measured TPP1/DNM2 pairs retain specific binding MODIFY terms. Official GO definitions describe binding to a protease/peptidase or GTPase; they do not assert regulation, effector activity or active-state specificity. Exact original Table S2 and positive IntAct pairs support these refinements, while the inherited abstract quotations only identify the study. Target-specific mammalian validation, physiological colocalization and insert boundaries remain unresolved. The two older questions on additional substrates and direct-versus-secondary fission effects are restored alongside the distinct topology and PPTC7 gaps. DRAFT remains the computed status because the authentic inherited Falcon report is not cited by an annotation; no provider citation is invented.