AKAIN1 (C18orf42) is a neural-tissue-enriched protein that engages the cAMP-dependent protein kinase A (PKA) signaling system through direct binding to PKA regulatory subunits, specifically the type II regulatory subunits, as shown by reciprocal immunoprecipitation and pull-down of the endogenous CRISPR-tagged protein in Neuro2a cells PMID:25653177. Its preferential expression in neural tissues positions this interaction in a defined cellular context PMID:25653177. Beyond this regulatory-subunit binding and its neural expression, no further mechanistic detail has been characterized in the available corpus.
| Year | Confidence | Finding | PMIDs | Journal |
|---|---|---|---|---|
| 2015 | Medium | C18orf42 (AKAIN1) encodes a protein that physically interacts with PKA regulatory subunits, specifically binding to the type II regulatory subunits of cAMP-dependent protein kinase A (PKA), as demonstrated by immunoprecipitation and pull-down assays in the Neuro2a neural cell line. | PMID:25653177 | Genes to cells : devoted to molecular & cellular mechanisms |
| 2015 | Low | C18orf42 (AKAIN1) expression blocks AKAP-mediated subcellular localization of PKA, suggesting it functions as an endogenous disruptor peptide for PKA-AKAP interactions, thereby potentially regulating PKA substrate specificity. | PMID:25653177 | Genes to cells : devoted to molecular & cellular mechanisms |
| 2015 | Medium | C18orf42 (AKAIN1) is preferentially expressed in neural tissues, as established by expression analysis in the study that characterized the endogenous protein. | PMID:25653177 | Genes to cells : devoted to molecular & cellular mechanisms |