Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Perforin-2 restricts growth of Chlamydia trachomatis in macrophages.

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria.

Regulation of expression and trafficking of perforin-2 by LPS and TNF-α.

Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection.

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.

MPEG1/Perforin-2 Haploinsufficiency Associated Polymicrobial Skin Infections and Considerations for Interferon-γ Therapy.

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells.

Perforin-2 enhances antigen-specific CTL immune response by promoting cross presentation.

Anchoring of perforin-2 via the transmembrane domain is required for antigen escape into the cytosol.