Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE.
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The AD-associated mtSNP rs2853499 (m.12372) is synonymous for MT-ND5 but changes codon 47 of the SHMOOSE ORF (D47N); association is modest and confounded by haplogroup U.
"mtSNP 12372 (rs2853499) does change the amino acid sequence of a microprotein encoded by a sORF that we ultimately called SHMOOSE"
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SHMOOSE contains no codons read differently by the mitochondrial code, so its sequence does not reveal where it is translated.
"SHMOOSE does not contain such mitochondrial-specific codon usage and is translated into identical sequences regardless of codon specificity"
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Synthetic SHMOOSE (not D47N) raised basal oxygen consumption of neuronal cells.
"compared to SHMOOSE.D47N, wild type SHMOOSE significantly increased basal oxygen consumption rate by approximately 20%"
Correction: Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE.
Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin-Nox2 interaction in cardioprotection.
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Independently states the ORF coordinates as m.12234-12410, matching the local sequence mapping.
"SHMOOSE is encoded by a small open reading frame (smORF) overlapping the serine tRNA region, between nucleotides 12,234 and 12,410"
UniProt entry C0HM83 (Protein SHMOOSE)
SHMOOSE ORF location and genetic-code check
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The ORF maps to rCRS m.12234-12410 (+ sense), overlapping MT-TS2, MT-TL2 and the 5' end of MT-ND5 in another frame, and translates identically under the standard and vertebrate mitochondrial codes.