Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells.
EphB4 expression and biological significance in prostate cancer.
Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity.
EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Erythropoietin Stimulates Tumor Growth via EphB4.
Architecture of the human interactome defines protein communities and disease networks.
Germline Loss-of-Function Mutations in EPHB4 Cause a Second Form of Capillary Malformation-Arteriovenous Malformation (CM-AVM2) Deregulating RAS-MAPK Signaling.
Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Multimodal cell maps as a foundation for structural and functional genomics.
Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.
EPH receptors autophosphorylate
EPH:EFN tetramers oligomerise
p190RhoGEF exchanges GTP for GDP on RHOA, activating it
N-WASP binds ARP2/3 and G-actin
EPH:EFN dimers tetramerise
Recruitment of p190RhoGEF to p-FAK
CDC42 and PIP2 bind WASL, activating it
SFKs phosphorylate VAV2,3
KALRN exchanges GTP for GDP on RAC1, activating it
EPHB phosphorylates TIAM1
VAV exchanges GTP for GDP on RAC1, activating it
bPIX exchanges GTP for GDP on RAC, activating it
Clathrin internalises EPH:EFN complexes
gamma-secretase cleaves EPHB2
Ras:GTP binds p120-RasGAP
p-EPHB phosphorylates SDC2
p-TIAM1 exchanges GTP for GDP on RAC1, activating it
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development.
EphB4 controls blood vascular morphogenesis during postnatal angiogenesis.
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion.
EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.