Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei.
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SRPN2 knockdown causes spontaneous melanotic pseudotumors and reduced lifespan
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SRPN2 knockdown reduces Plasmodium oocyst numbers by 97% through enhanced ookinete melanization
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SRPN2 is secreted into the hemolymph
Characterization of a regulatory unit that controls melanization and affects longevity of mosquitoes.
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CLIPB9 is a PPO-activating proteinase inhibited by SRPN2
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SRPN2-CLIPB9 is the first characterized inhibitory serpin-protease pair in mosquitoes
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Double knockdown of SRPN2 and CLIPB9 reverses the SRPN2-knockdown phenotype
Structural and inhibitory effects of hinge loop mutagenesis in serpin-2 from the malaria vector Anopheles gambiae.
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SRPN2 irreversibly inhibits CLIPB9 via classic serpin mechanism
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Crystal structures reveal hinge region function in serpin-protease complex formation
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Kinetic analysis of SRPN2-CLIPB9 inhibition
The CLIP-domain serine protease CLIPC9 regulates melanization downstream of SPCLIP1, CLIPA8, and CLIPA28 in the malaria vector Anopheles gambiae.
CLIPB10 is a Terminal Protease in the Regulatory Network That Controls Melanization in the African Malaria Mosquito Anopheles gambiae.
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SRPN2 directly inhibits CLIPB10 with stoichiometry of 1.89
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SRPN2 forms SDS-stable complex with CLIPB10
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CLIPB10 knockdown partially rescues SRPN2-knockdown melanotic tumor phenotype