Automatic Gene Ontology annotation of non-coding RNA sequences through association of Rfam records with GO terms
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
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miR-100 is one of three miRNAs the study functionally validates: Smarca5 is a direct target, anti-miR suppression blocks differentiation, and overexpression alters differentiation markers.
"we first demonstrated that Smarca5 is a direct target of miR-100"
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The same study reports 138 miRNAs rising during differentiation, which was induced by withdrawing LIF; those 138 were not individually tested.
"We report that 138 miRNAs are increased on the induction of differentiation"
Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss.
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An age-related expression survey of the organ of Corti in two mouse strains, reporting 111 and 71 differentially expressed miRNAs and framing the result as correlative.
"Our study suggests that changes in miRNA expression precede morphological and functional changes"
miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.
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372 miRNAs were detected, only 12 changed during LTP, and only miR-26a, miR-384-5p and let-7a were shown to be required. mir-100 is not mentioned anywhere in the paper.
"Of the 12 miRNAs changed in LTP, 6 were down- and 6 were upregulated"
Primary microRNA precursor transcripts are localized at post-synaptic densities in adult mouse forebrain.
miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation.
Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination.