MLO2 (Arabidopsis thaliana, Q9SXB6, At1g11310) notes

Sources: UniProt, GOA (12 rows), falcon deep research, cached papers (full text:
PMID:35794475, 37767715, 38124479, 28674541; abstract only: 10677553, 16525893,
16732289, 32156686). New PMIDs verified via PubMed citation lookup.

Identity / structure

• Clade V MLO, co-ortholog of barley MLO with MLO6, MLO12; 7TM, cytosolic C-terminal CaMBD
  [file:ARATH/MLO2/MLO2-deep-research-falcon.md "MLO2 is a plant-specific, seven-transmembrane protein"].
• PM localization: PMID:38124479.
  Golgi-associated puncta reported by deep research (Qin 2020; abstract-only cache, not quoted directly).

Molecular function

• Ca2+ channel, heterologous: PMID:35794475;
  PMID:35794475.
• CaM feedback: PMID:35794475.
• CAM2 binding, LW/RR mutant reduces binding in most assays PMID:37767715.

Process (necessity, not participation in defense)

• PMID:16732289.
• mlo2 partial, triple full resistance PMID:38124479.
• PMID:28674541.
• Trichome wall/EXO70H4 phenotype is triple-mutant only PMID:38124479.

Decisions

• defense response (IEA) and defense response to fungus (IMP) -> MODIFY to GO:0031348
  negative regulation of defense response (consistent with HORVU/MLO review).
• GO:0031348 IMP ACCEPT; response to fungus KEEP_AS_NON_CORE.
• ND MF -> MODIFY; NEW calcium channel activity (IDA PMID:35794475), calmodulin binding (IDA PMID:37767715).
• extracellular region (HDA) and chloroplast (ISM) REMOVE; Golgi, plasmodesma KEEP_AS_NON_CORE.
• No NEW BP terms: no defense term passes participation; calcium ion transmembrane
  transport not added because only heterologous evidence and in planta role unknown.