Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.
TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.
TRAPP Complexes in Secretion and Autophagy.
A reference map of the human binary protein interactome.
TRAPPC complexes exchange GTP for GDP on RAB1
Mutations in TRAPPC12 Manifest in Progressive Childhood Encephalopathy and Golgi Dysfunction.
UniProtKB record for TRAPPC12
OpenScientist hypothesis run: TRAPPC12 kinetochore moonlighting
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TRAPPC12's ER-to-Golgi TRAPP role is independently corroborated, while the mitotic CENP-E/kinetochore branch rests mostly on a single primary study.
"the kinetochore role is essentially **one primary paper from one group**"
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A phosphorylation-regulated TRAMM/TRAPPC12 pool that helps recruit CENP-E is plausible, but direct TRAMM-CENP-E binding and a trafficking-competent mitosis-dead separation-of-function allele are still missing.
"true separation of function is **incomplete**"