Manual PSEN1 curation notes
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1.
Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1.
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.
Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice.
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.
X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains.
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.
Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules.
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein.
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1).
A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations.
Purification and characterization of the human gamma-secretase complex.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem.
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.
Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.
Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.
Cellular localization of Nicastrin affects amyloid beta species production.
Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.
Memory impairment in transgenic Alzheimer mice requires cellular prion protein.
Activation and intrinsic gamma-secretase activity of presenilin 1.
Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo.
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.
Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation.
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.
G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
The miR-193a-3p regulated PSEN1 gene suppresses the multi-chemoresistance of bladder cancer.
Quantitative interaction proteomics of neurodegenerative disease proteins.
Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes.
An atomic structure of human γ-secretase.
Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress.
Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.
Intracellular trafficking of TREM2 is regulated by presenilin 1.
Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Two homologous genes causing early-onset familial Alzheimer's disease.
Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation.
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin.
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.
Direct association of presenilin-1 with beta-catenin.
Cleavage of ERBB4m80 by gamma-scretase complex
gamma-secretase cleaves the p75NTR transmembrane domain
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
gamma-secretase cleaves EPHB2
Exocytosis of azurophil granule membrane proteins
NEXT3 is cleaved to produce NICD3
Gamma-secretase cleaves YBX1:NOTCH3
TGFBR3(784-851) degradation
Gamma-secretase complex cleaves mNEXT2
Gamma-secretase cleaves Notch4