SFA1 (YDL168W, P32771) notes

Evidence journal

• Class III ADH / glutathione-dependent formaldehyde dehydrogenase PMID:7649298.
• Formaldehyde resistance and degradation PMID:8483449; oxidises long-chain alcohols PMID:8483449.
• GSNO reductase PMID:11260719.
• Ehrlich final step: one of six redundant reductases PMID:12499363.
• Cytoplasmic by GFP, also detected in mitochondrial proteomes [UniProt:P32771].
• HMF reductase IMP (PMID:16652391): abstract only describes ADH6; SFA1 data not visible -> UNDECIDED.

Curation decisions

• Core: S-(hydroxymethyl)glutathione dehydrogenase (formaldehyde catabolism), GSNO reductase, NAD-ADH (leucine Ehrlich step, redundant).
• Valine/isoleucine/phe/trp Ehrlich RCA rows kept as non-core; leucine IGI accepted.