Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
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RAB9A annotations inferred from phylogenetic analysis including orthologs in mouse, rat, fly, worm, and yeast
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange.
Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene.
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.
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RAB9A (as GFP-rab9) localizes to late endosomes and some lysosomes
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Little overlap between mVPS26 (retromer) and GFP-rab9, suggesting distinct but related pathways
High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target.
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1.25 angstrom crystal structure of Rab9 (residues 1-177) with GDP bound
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Confirms GTPase fold with nucleotide binding site
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Identified as potential antiviral drug target due to role in HIV-1, Ebola, Marburg, measles virus replication
Rab and Arl GTPase family members cooperate in the localization of the golgin GCC185.
The Salmonella virulence protein SifA is a G protein antagonist.
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SKIP binds Rab9 in a GTP-dependent manner
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Rab9 and SKIP function to maintain peripheral LAMP1 distribution
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SifA can antagonize Rab9 binding to SKIP
Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway.
RhoBTB3 a Rho GTPase-family ATPase required for endosome to Golgi transport.
Rab27a and Rab27b control different steps of the exosome secretion pathway.
Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.
RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.
Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.
RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.
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RUTBC1 binds Rab9A-GTP but is not a GAP for Rab9A
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RUTBC1 has GAP activity for Rab32 and Rab33B
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Supports model of Rab9A and Rab32 acting in adjacent pathways
Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex.
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Crystal structure of Rab9A-GTP with NDE1 at 2.45 angstrom resolution
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NDE1/NDEL1 are Rab9 effectors linking late endosomes to dynein motor
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Two RAB9A-GTP molecules bind on opposite sides of NDE1 homodimer
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Essential for retrograde transport of late endosomes to TGN
ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation
Fusion of late-endosome derived vesicles at the TGN
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins
RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN
RAB9 GEFs exchange GTP for GDP on RAB9
RHOBTB3 binds interacting proteins at trans-Golgi network
Deep research review of RAB9A function
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RAB9A encodes a small Rab GTPase that regulates late endosome-to-TGN retrograde transport
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Core effectors include TIP47/PLIN3 for cargo selection and GCC185 for vesicle tethering
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Rab9 depletion reduces late endosome diameter by approximately 45 percent
Cyberian deep research on RAB9A function