Cem1 is a mitochondrial beta-ketoacyl-ACP synthase of the dissociated type II fatty-acid synthesis machinery. Its conserved ketoacyl-synthase domains and catalytic residues support malonyl-ACP-dependent two-carbon acyl-chain extension. Transfer from characterized mitochondrial OXSM/Cem1 homologs supports a role in producing acyl-ACP intermediates needed for mitochondrial metabolism, while its exact substrate range in fission yeast remains unresolved.
Evidence interpretation: sequence/domain records are used for family placement; AI descriptions and ARBA labels are not independent validation. Family transfer is limited to conserved properties and is identified as inference. Genome-scale localization annotations are retained where consistent with the biology; an abstract does not expose every individual observation. All original annotation rows are preserved.
ProtNLM provenance: pre-release post-processed-2026_02_28k.xml, exact entry and all evidence keys preserved in the source XML/JSON. These current Swiss-Prot entries are absent from the public TrEMBL pilot. Known-function overlap does not establish model training membership. See the function sidecar for atom-by-atom paragraph assessments.
Research provenance: the gene-focused Falcon report was generated concurrently with publication caching. The report was inspected for source leads; the biological decisions above rely on the cited primary records and specified family evidence.
The completed Falcon search has retrieval gaps: its inability to locate target-level localization is not used to override PomBase’s HDA records. Curated genomic-screen observations and the directly inspected papers take precedence over an empty literature-search result.