Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Pseudomonas aeruginosa AmpR is a global transcriptional factor that regulates expression of AmpC and PoxB beta-lactamases, proteases, quorum sensing, and other virulence factors.
The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes.
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AmpR regulon defined by microarray of the ampR deletion; direct targets not identified.
"Studies aimed at identifying the direct targets of AmpR are needed to identify genes that are directly regulated by AmpR"
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ampR deletion increases biofilm formation.
"over a period of 72 hours indicating that AmpR is a negative regulator of biofilm formation"
Structural and functional characterization of Pseudomonas aeruginosa global regulator AmpR.
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AmpR binds the ampC promoter in vitro and in vivo.
"Gel shifts using membrane fractions showed that AmpR binds to PampC in vitro whereas in vivo binding was demonstrated using chromatin immunoprecipitation-quantitative PCR (ChIP-qPCR)."