Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.
The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and the PDGF receptor exist in a complex that is dependent on hydrophobic transmembrane interactions.
CpG island in the region of an autosomal dominant polycystic kidney disease locus defines the 5' end of a gene encoding a putative proton channel.
-
Original cloning of human ATP6V0C
"a 155-amino acid peptide having four putative transmembrane domains"
-
Identified as 155 amino acid protein with four transmembrane domains
"a 155-amino acid peptide having four putative transmembrane domains"
-
Homologous to vacuolar H+-ATPase 16 kDa proteolipid
"93% similarity to the 16-kDa proteolipid component"
Integral and associated lysosomal membrane proteins.
A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation.
-
RNF182 interacts with ATP6V0C
"an interaction between RNF182 and ATP6V0C"
-
RNF182 targets ATP6V0C for ubiquitin-proteasome degradation
"RNF182 targeted ATP6V0C for degradation by the ubiquitin-proteosome pathway"
-
Potential relevance to Alzheimer's disease
"up regulated in the brains of Alzheimer's patients"
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.
-
V-ATPase required for Wnt/beta-catenin signaling
"PRR and V-ATPase were required to mediate Wnt signaling"
-
PRR/ATP6AP2 functions as adaptor between Wnt receptors and V-ATPase
"PRR functions in a renin-independent manner as an adaptor between Wnt receptors and the vacuolar H+-adenosine triphosphatase"
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Toward an understanding of the protein interaction network of the human liver.
Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.
A proteome-scale map of the human interactome network.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Structure and Roles of V-type ATPases.
-
Comprehensive review of V-ATPase structure and function
"V-ATPases are membrane-embedded protein complexes that function as ATP hydrolysis-driven proton pumps"
-
V-ATPases essential for organellar acidification
"V-ATPases are the primary source of organellar acidification in all eukaryotes"
-
Multiple V-ATPase isoforms with differential localization
"several subunits of mammalian V-ATPase have multiple isoforms that are differentially localized"
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
-
Interactome study in neurodegeneration context
"Here, we report on an interactome map that focuses on neurodegenerative disease"
Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
-
Cryo-EM structures of human V-ATPase at up to 2.9 A resolution
"we report cryoelectron microscopy structures of human V-ATPase in three rotational states at up to 2.9-Å resolution"
-
Nine copies of ATP6V0C (subunit c) form c-ring with one copy of ATP6V0B (c'')
"a membrane-embedded Vo complex for proton transfer"
-
ATP6AP1 serves as assembly hub connecting V0 subunits
"We define ATP6AP1 as a structural hub for Vo complex assembly because it connects to multiple Vo subunits"
-
Identified glycolipids and phospholipids in V0 complex
"identify glycolipids and phospholipids in the Vo complex"
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
ATP6V0C variants impair V-ATPase function causing a neurodevelopmental disorder often associated with epilepsy.
-
Pathogenic variants in ATP6V0C cause EPEO3 (epilepsy with developmental delay)
"ATP6V0C variants impair V-ATPase function causing a neurodevelopmental disorder"
-
E139 is essential for proton translocation
"the patient variants interfere with the interactions between the ATP6V0C and ATP6V0A subunits"
-
Multiple variants characterized for effects on V-ATPase function
"variants impair V-ATPase function"
Deep research summary of ATP6V0C function and localization
-
Comprehensive literature review of ATP6V0C function
-
Synaptic vesicle acidification required for neurotransmitter loading
-
V-ATPase-Ragulator complex essential for mTORC1 activation
Falcon deep research summary of ATP6V0C function and PN-relevant V-ATPase biology
-
Falcon summarizes ATP6V0C as the V0 c proteolipid/c-ring component of human V-ATPase.
"ATP6V0C encodes the c proteolipid subunit of the membrane Vo sector of the V‑type H+‑ATPase (V‑ATPase) in Homo sapiens"
-
Falcon supports lysosomal acidification and autophagic cargo degradation as downstream outcomes of V-ATPase acidification.
"V‑ATPase‑driven acidification is essential for lysosomal hydrolase activity and endocytic/autophagic cargo degradation"
ATP6V0C curation notes, including Proteostasis PN re-review
Cyberian deep research on ATP6V0C function
V-ATPase Ragulator Rag complex dissociation with SLC38A9
V-ATPase Ragulator Rag binding to SLC38A9 Arginine
V-ATPase Ragulator Rag binding to mTORC1
mTORC1 binding to RHEB GTP
MITF-M-dependent ATP6V0C gene expression
Exocytosis of azurophil granule membrane proteins
Exocytosis of tertiary granule membrane proteins
Exocytosis of ficolin-rich granule membrane proteins
ATP6AP1 binding to V-ATPase
Acidification of transferrin transferrin receptor containing endosome