Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
UniProtKB record for P04522 (EXO2_BPT4)
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gp46 forms a two-subunit exonuclease complex with gp47 that participates in viral genome replication, DNA recombination, and host DNA degradation.
"FUNCTION: Exonuclease that plays a role in viral genome replication, DNA recombination, and host DNA degradation."
Deep research summary for Enterobacteria phage T4 gene 46 (gp46)
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gp46 is the Rad50-family ABC ATPase subunit of the T4 Mre11-Rad50 complex whose ATPase activity is stimulated ~20-fold by gp47 and dsDNA to drive processive DNA end resection during double-strand break repair and recombination-dependent replication.
"The modern consensus from genetics and biochemistry is that gp46 is the **Rad50-family ATPase subunit** of a phage **Mre11–Rad50 (MR)–like DNA end-processing complex** formed with **gp47 (Mre11 homolog)**; this complex is required in vivo for **homologous recombination, recombination-dependent DNA replication (RDR), and double-strand break (DSB) repair**."
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ATP hydrolysis by gp46 is strongly activated by gp47 and dsDNA and promotes processive nuclease action by gp47.
"Current model: gp46 **binds/hydrolyzes ATP at the Rad50 head dimer interface**; ATP-driven conformational cycling promotes assembly at DNA ends and transitions to a **translocation state** that supports processive nuclease action by gp47."