pmrB (PA4777, Q9HV31) review notes

Review session 2026-11-05 (PseudoCAP IBA-seed protocol, tier 2)

Fetched with just fetch-gene PSEAE Q9HV31 --alias pmrB; accession matches the worklist. No
deep-research provider used. PMID:14507375 is abstract-only (no PMC record).

Literature

PMID:14507375
PMID:14507375
UniProt: two TM helices, HAMP, HisKA (His249 phosphohistidine), HATPase. No receiver or HPt domain.
pmrB carries no GO:0009927 histidine phosphotransfer kinase row, so the HPt problem recorded on
PA1611 and pfeS does not arise here.

Annotation decisions

ACCEPT: GO:0000155 (IEA), GO:0000160 (IBA, IDA seed, IEA), GO:0005886 (IBA).
TOO_GENERAL: GO:0004673 (IEA, ISS), GO:0016772, GO:0007165, GO:0016020.
PSEUDOCAP WRONG_EVIDENCE_CODE (CHECK, SUSPECTED) on the IDA GO:0000160 row, as for pfeS.
Action counts: ACCEPT 5, TOO_GENERAL 5.

PseudoCAP IBA-seed assessment

PTN001976770 is not shared with the reviewed sensor kinases (parS, PA5484, pprA, fleS, cbrA, PA1611,
PA3271, pfeS); no node term in it is GO:0009927.

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN001976770	GO:0000160 phosphorelay signal transduction system	3	71 (24 taxa)	GO:0000160, IDA, PMID:14507375 (PseudoCAP)	UNVERIFIABLE	Abstract only; it reports mutants and reporter fusions, no PmrB assay. The term is true of PmrB, but whether IDA-type evidence exists could not be checked.	E. coli PhoQ P23837, O69729	Yes; the term suits a sensor-kinase clade