The downloaded human Q9Y616 sequence (596 residues) and selected horse A0A3Q2HDT6 sequence (567 residues) share 80.7% identity among 554 paired residues. Paired coverage is 93.0% of human and 97.7% of horse.
Full alignment, hashes, parameters and reproducible script: IRAK3.json and compare.py.
Pairwise similarity supports homology but does not establish reciprocal orthology, intact gene models, conservation of targeting signals or every biological claim. Current UniProt sequences are compared; identity with the original ProtNLM input sequence is unverified.
The selected horse sequence lacks human residues 2–43, reaching the beginning of the annotated death domain at residues 41–106. The kinase-like domain is retained. Receptor-complex assembly requires caution because the N-terminal interaction region is shortened.