C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180.
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ced-5 encodes a DOCK180/Myoblast City homologue
"encodes a protein that is similar to the human protein DOCK180 and the Drosophila melanogaster protein Myoblast City (MBC)"
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ced-5 is required for corpse engulfment and distal tip cell migration
"ced-5 mutants are defective not only in the engulfment of cell corpses but also in the migrations of two specific gonadal cells, the distal tip cells"
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Human DOCK180 rescues the ced-5 migration defect
"The expression of human DOCK180 in C. elegans rescued the cell-migration defect of a ced-5 mutant"
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ced-5 acts in engulfing cells
"We present evidence that ced-5 functions in engulfing cells during the engulfment of cell corpses"
Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.
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ced-5 identified as an engulfment gene
"We have identified five new genes that play a role in this process: ced-5, ced-6, ced-7, ced-8 and ced-10"
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans.
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CED-2 and CED-5 interact physically and act upstream of CED-10/Rac
"We propose that CED-2/CrkII and CED-5/DOCK180 function to activate CED-10/Rac in a GTPase signalling pathway that controls the polarized extension of cell surfaces"
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
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CED-12/ELMO binds CED-5/DOCK180 directly; the complex acts as a Rac GEF
"CED-12/ELMO-1 binds directly to CED-5/Dock180; this evolutionarily conserved complex stimulates a Rac-GEF, leading to Rac1 activation and cytoskeletal rearrangements"
The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.
C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.
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CED-2, CED-5 and CED-12 form a ternary complex proposed to act at the plasma membrane
"We propose that the formation and localization of a CED-2-CED-5-CED-12 ternary complex to the plasma membrane activates CED-10"
Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.
Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.
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CED-2 binds the N-terminal region of CED-5; the PXXP contact is dispensable for rescue
"A CED-2 point mutation (F125G) disrupting its interaction with the PXXP motif of CED-5 did not affect its rescuing activity"
The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
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MOM-5/Frizzled activates CED-10 through the CED-2/CED-5/CED-12 GEF complex
"The epistatic and bypass experiments indeed indicate that MOM-5/Fz activates CED-10/Rac through the GEF complex CED-2, CED-5, CED-12"
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ced-5 single mutants fail to engulf most first-wave embryonic corpses
"Approximately 70% of cells dying in the first wave of embryonic apoptosis failed to be engulfed in mom-5, ced-5, or ced-10 single mutants"
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CED-5 overexpression suppresses the mom-5 distal tip cell migration defect
"overexpression of both CED-5 and CED-10 significantly suppressed the mom-5 DTC migration defect"
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Spindle orientation probably does not go through CED-2/5/12
"neither apr-1 nor any of the other ced genes showed a strong defect, suggesting that the link to CED-10 may not occur through CED-2/5/12 as is the case for engulfment and DTC migration"
Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans.
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ced-5 functions redundantly with hmr-1 in gastrulation
"ced-5, which encodes a DOCK180-like guanine exchange factor for Rac (Wu and Horvitz 1998) and hmr-1, which encodes a classical cadherin (Costa et al. 1998), function redundantly in C. elegans gastrulation"
Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.
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Unengulfed cells in engulfment mutants still undergo CED-3-mediated apoptosis
"cells that undergo CED-3-mediated apoptosis and detach from the embryo because they cannot be internalized by engulfing cells"
Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization.
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ced-5 is used as an engulfment-defective background
"ced-8(n1891) markedly enhanced the cell corpse engulfment defect of the ced-2, ced-5 or ced-12 mutants"
Phagocytosis promotes programmed cell death in C. elegans.
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Engulfment genes, including ced-5, promote programmed cell death
"the engulfment of dying cells requires the genes ced-1, ced-2, ced-5, ced-6, ced-7, ced-10 and ced-12"
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans.
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt