Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs.
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling.
Developmental genetics of the Drosophila gut: specification of primordia, subdivision and overt-differentiation.
Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?
Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.
Tissue- and stage-specific modulation of Wingless signaling by the segment polarity gene lines.
Genetics of heart development.
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus.
Regulation of pattern formation in the Drosophila hindgut by wg, hh, dpp, and en.
Sticking together and sorting things out: adhesion as a force in development.
Hedgehog acts as a somatic stem cell factor in the Drosophila ovary.
Hedgehog signaling patterns the tracheal branches.
Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.
The development of the Drosophila genital disc.
The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells.
Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes.
Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused.
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog.
Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division.
Pattern formation in the Drosophila wing: The development of the veins.
Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila.
Cell migration and programmed cell death of Drosophila germ cells.
Evolution in black and white: genetic control of pigment patterns in Drosophila.
The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog.
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog.
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.
How are the sizes of cells, organs, and bodies controlled?
Regulation of Hedgehog signaling: a complex story.
The evolution of arthropod segmentation mechanisms.
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction.
Extensive phosphorylation of Smoothened in Hedgehog pathway activation.
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.
Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts.
The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog.
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.
Allocation and specification of the genital disc precursor cells in Drosophila.
Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis.
Developmental analysis and squamous morphogenesis of the peripodial epithelium in Drosophila imaginal discs.
HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster.
Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms.
Determination of cell fate along the anteroposterior axis of the Drosophila ventral midline.
Role of the Drosophila patched gene in positional signalling.
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.
Structure of a heparin-dependent complex of Hedgehog and Ihog.
Quantitative analysis of Hedgehog gradient formation using an inducible expression system.
Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors.
Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation.
Hedgehog regulates smoothened activity by inducing a conformational switch.
Patched, the receptor of Hedgehog, is a lipoprotein receptor.
Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila.
PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation.
Hedgehog does not guide migrating Drosophila germ cells.
Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.
Genetic and biochemical definition of the Hedgehog receptor.
The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum.
Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling.
Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.
The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation.
Distinct phosphorylations on kinesin costal-2 mediate differential hedgehog signaling strength.
Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner.
Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration.
A rapid genome-wide microRNA screen identifies miR-14 as a modulator of Hedgehog signaling.
Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation.
Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.
Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.
A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.
PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.
Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway.
Dose-dependent transduction of Hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor Smoothened and the kinase Fused.
Cytoneme-mediated cell-cell contacts for Hedgehog reception.
Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.
Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing.
Protein association changes in the Hedgehog signaling complex mediate differential signaling strength.
The Drosophila Hedgehog receptor component Interference hedgehog (Ihog) mediates cell-cell interactions through trans-homophilic binding.
Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.
The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.
Dissection of the microRNA Network Regulating Hedgehog Signaling in Drosophila.
High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened.
Dose-dependent phosphorylation and activation of Hh pathway transcription factors.
Morphogen-induced kinase condensates transduce Hh signal by allosterically activating Gli.
Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila.
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.
Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication.
The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye.
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs.
The wingless signaling pathway is directly involved in Drosophila heart development.
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling.
Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs.
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor.
Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.
Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila.
Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.
N-HH binds to PTC receptor complex
N-HH moves from the cytosol to the extracellular region
N-HH binds to the transmembrane HSPG proteins
N-HH is palmitoylated by RASP