Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse.
Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1.
Identification and characterization of two G protein-coupled receptors for neuropeptide FF.
Activation-induced subcellular redistribution of G alpha(s) is dependent upon its unique N-terminus.
Opsin-G11-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock.
The GPR54 gene as a regulator of puberty.
Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction.
beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
Molecular cloning, structural characterization and functional expression of the human substance P receptor.
Integral and associated lysosomal membrane proteins.
Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.
RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.
Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.
Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.
Identification of G protein alpha subunit-palmitoylating enzyme.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Regulation of GSK-3beta and beta-Catenin by Galphaq in HEK293T cells.
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.
Kinetic scaffolding mediated by a phospholipase C-beta and Gq signaling complex.
A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPK.
Direct inhibition of the cold-activated TRPM8 ion channel by Gαq.
β-Arrestin-1 directly interacts with Gαs and regulates its function.
Parathyroid hormone (PTH) and PTH-related peptide domains contributing to activation of different PTH receptor-mediated signaling pathways.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
A novel Gαs-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.
GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent Signaling.
ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma.
mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor.
In silico design of novel probes for the atypical opioid receptor MRGPRX2.
MRGPRX4 is a bile acid receptor for human cholestatic itch.
The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.
A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer.
Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Structure, function and pharmacology of human itch receptor complexes.
Deletion of Gαq/11 or Gαs Proteins in Gonadotropes Differentially Affects Gonadotropin Production and Secretion in Mice.
The electrophysiologic properties of gonadotropin-releasing hormone neurons.
Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists.
The mechanism of Gα(q) regulation of PLCβ3-catalyzed PIP2 hydrolysis.
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Gq directly increases PLCbeta3 catalytic activity, rather than supplying phospholipase catalysis itself.
"Gαq increases the catalytic rate constant, kcat, of PLCβ3."
Promiscuous G-protein activation by the calcium-sensing receptor.
Agonist-selective activation of individual G-proteins by muscarinic receptors.
Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.
Molecular basis of proton sensing by G protein-coupled receptors.
Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.
Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq.
Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association.
Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses.
Defective platelet activation in G alpha(q)-deficient mice.
The receptor:G-protein complex dissociates
Thrombin-activated PARs activate Gq
PLC-beta hydrolyses PIP2 to DAG and IP3
The high affinity receptor complex binds to G-protein
G-protein alpha subunit is inactivated
The receptor:G-protein complex releases GDP
The receptor:G-protein complex binds GTP
G-protein beta-gamma subunits rebind the alpha-GDP subunit
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
Thrombin-activated PARs binds G-protein Gq
Thrombin-activated PARs:Gq (active) dissociate
G alpha (q) binds to Trio family RhoGEFs
G alpha (q) inhibits PI3K alpha
GRK2 sequesters activated Gq
Dissociation of the P2Y purinoceptor 1:Gq complex
G alpha (q) auto-inactivates by hydrolysing GTP to GDP
Activated TP receptor binds G-proten Gq
Gq activation by TP receptor
Dissociation of the TP:Gq complex
P2Y purinoceptor 1 activates MAP kinase p38 alpha
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
The Ligand:GPCR:Gq complex dissociates
Inactive G alpha (q) reassociates with G beta:gamma
G-protein alpha releases G-protein heterotrimer from PDCL
BTK in active Gq-BTK complex is activated
Gq-BTK complex dissociates to Active BTK and Gq
Active G alpha (q) binds RGS proteins
G alpha (q) in G (q):RGS complex is inactivated
G alpha (q):RGS dissociates to inactive G alpha (q)
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT(2A) Serotonin Receptor.
Using siRNA to define functional interactions between melanopsin and multiple G Protein partners.
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Mouse cellular assays establish separate Gnaq and Gna11 melanopsin-signaling capacity; native combined knockdown supports overlapping contributions, with human involvement inferred comparatively.
"These data confirm that Gnaq and Gna11 convey the melanopsin signal in Neuro-2A cells."
Loss of gq/11 genes does not abolish melanopsin phototransduction.
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Retained responses after tested mouse single/double losses constrain essentiality; possible compensation prevents interpreting these results as absence of participation.
"Another possibility is that there is compensatory upregulation from other remaining Gq/11 family members in the tested mutant lines."