GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:31313987

Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive.

A hypomorphic Tdh (CG5955) allele raises threonine levels and increases sleep drive; pan-neuronal Tdh knockdown shortens sleep latency.

"Loss-of-function mutations in CG5955 promoted sleep."

PMID:36810287

Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models.

Tdh (CG5955) is upregulated by time-restricted feeding and its flight-muscle knockdown causes muscle dysfunction and ectopic lipid accumulation.

"Muscle-specific knockdown of Gnmt, Sardh, and CG5955 lead to muscle dysfunction, ectopic lipid accumulation, and loss of TRF-mediated benefits"

file:DROME/Tdh/Tdh-uniprot.txt

DROME/Tdh/Tdh-uniprot.txt